Heavier items such as fusion cores, rockets, and mini-nukes can really drag you down.
If you wish to be somewhere, you'll have to physically travel there. You can increase the damage you deal even further with 'Adrenaline' (see below). You now deal, but also take, more damage. To save your game, you'll need to find a bed and sleep for at least an hour. The following is a list of changes experienced in Survival Mode: